What is a common use for actinomycin D in cancer treatment?

Actinomycin D is primarily used in the treatment of certain types of cancers, with a notable application in the management of testicular cancer. This drug works as a chemotherapy agent by inhibiting DNA-dependent RNA synthesis, which ultimately leads to the death of rapidly dividing cancer cells. Its efficacy in testicular cancer is particularly due to the sensitivity of germ cell tumors to various chemotherapeutic agents, of which actinomycin D is one.

While actinomycin D may have some relevance in the treatment of various other cancers, it is most prominently and effectively utilized in the context of testicular cancer, where it can be part of combination chemotherapy regimens. The other cancers listed have different standard treatment protocols and specific chemotherapeutic agents that are more commonly utilized or that have shown better response rates compared to actinomycin D.