What is a known hypersensitivity reaction that can occur after late doses of which chemotherapy agent?

Carboplatin is associated with hypersensitivity reactions, particularly after repeated doses. This is primarily due to the way the drug is metabolized and its cumulative effects in the body. As patients receive more cycles of carboplatin, their immune system may develop an allergic response to the drug, leading to hypersensitivity. Symptoms can range from mild reactions, such as rash or itching, to more severe responses, including anaphylaxis.

The importance of recognizing this type of reaction is crucial in clinical practice, as it necessitates careful monitoring of patients undergoing treatment with carboplatin, especially after several cycles. Preventive measures and treatment protocols can be established for patients who have experienced prior reactions.

Other agents listed can have their own side effects and toxicities, but carboplatin is specifically noted for hypersensitivity reactions that become more pronounced with cumulative exposure, highlighting its distinct profile compared to the others.