What is the main purpose of administering Mesna in conjunction with certain chemotherapy agents?

The main purpose of administering Mesna alongside certain chemotherapy agents is to protect the bladder. Mesna is a synthetic compound that acts to prevent or minimize urotoxicity, which is a significant side effect associated with specific chemotherapy drugs, particularly ifosfamide and cyclophosphamide. These chemotherapy agents can lead to the formation of toxic metabolites that may cause bladder irritation or hemorrhagic cystitis. By providing a protective effect on the bladder, Mesna binds to these harmful metabolites and helps to neutralize their effects, thereby reducing the risk of bladder damage and associated complications during treatment. This strategy is crucial in managing patient safety and comfort during chemotherapy regimens.