What is the mechanism of action of antiandrogens?

Antiandrogens primarily function by keeping androgens from binding to androgen receptors, which is essential in managing conditions that are influenced by androgens, such as prostate cancer. By blocking the interaction between androgens (like testosterone and dihydrotestosterone) and their receptors, antiandrogens inhibit the signaling pathways that promote tumor growth and proliferation.

This mechanism is pivotal in therapeutic contexts, where the reduction of androgen activity can lead to decreased cancer cell growth and improved patient outcomes. In contrast, activating androgen receptors would lead to increased androgenic activity, which is contrary to the role of antiandrogens. Blocking estrogen receptors or inhibiting estrogen synthesis pertains to estrogen-targeting therapies and does not reflect the mechanisms of antiandrogens.